Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age

T. Ono, Y. Miyamura, H. Ikehata, H. Yamanaka, A. Kurishita, K. Yamamoto, T. Suzuki, T. Nohmi, M. Hayashi, T. Sofuni

研究成果: Article査読

46 被引用数 (Scopus)

抄録

Spontaneous mutant frequency of lacZ gene in spleen of transgenic Muta mouse was examined at different ages. It was (3.2 ± 1.3 (SD)) × 10-5 at newborn and increased almost linearly with age up to (8.3 ± 1.8) × 10-5 at one year. Since the mutation of the gene is not likely to be subject to selection in vivo, the data support the idea that spontaneous mutation takes place throughout aging process and accumulates with age if not selected out by cell death.

本文言語English
ページ(範囲)183-188
ページ数6
ジャーナルMutation Research DNAging
338
1-6
DOI
出版ステータスPublished - 1995 10月

ASJC Scopus subject areas

  • 加齢科学
  • 分子生物学
  • 遺伝学

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