Specific induction of hepatocellular adenomas by transplacental administration of ENU in the Tsc2 gene mutant (Eker) rat

Tomokazu Fukuda, Hiroaki Mitani, Masahiro Tsutsumi, Yoichi Konishi, Okio Hino

研究成果: Article査読

8 被引用数 (Scopus)

抄録

Eker rats develop dominantly inherited renal carcinomas (RCs), with hereditary mutation, and following somatic mutation (Knudson's second hit) at tuberous sclerosis gene (Tsc2). We document the effect of transplacental administration of N-ethyl-N-nitrosourea to Eker (Eker/+) and non-Eker (+/+) rats (same genetic background). Although we observed no difference in the number of preneoplastic 'traditional' GST-P positive loci between Eker and non-Eker rats, interestingly we observed the specific development of hepatocellular adenomas only in Eker rats. The Tsc2 gene mutation might thus influence the phenotype of preneoplastic initiated hepatocytes.

本文言語English
ページ(範囲)957-961
ページ数5
ジャーナルInternational Journal of Oncology
13
5
出版ステータスPublished - 1998 11 1

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

フィンガープリント

「Specific induction of hepatocellular adenomas by transplacental administration of ENU in the Tsc2 gene mutant (Eker) rat」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル