抄録
The Fab′ fragment of a monoclonal antibody (mAb) directed to CD3 (a portion of the T cell receptor) and the Fab′ or F(ab′)2 fragment of an mAb to HIV were combined to generate bifunctional antibody (BFA) consisting of antiCD3-Fab′ conjugated with anti-HIV-Fab′ (Fab′/Fab′) or antiCD3-Fab′ conjugated with anti-HIV-F(ab′)2 (Fab′/F(ab′)2), respectively. In the presence of these BFA, HIV-infected target cells were cytolysed by peripheral blood lymphocytes. Treatment of lymphocytes with Fab′/F(ab′)2 type BFA rendered the lymphocytes significantly cytotoxic to HIV-infected target cells. Since BFA-armed lymphocytes can react on HIV-infected cells regardless of histocompatibility, lymphocytes from healthy donors could be armed with BFA for treatment of HIV-infected patients including those who do not exhibit histocompatibility with the lymphocyte donor.
| 本文言語 | English |
|---|---|
| ページ（範囲） | 247-252 |
| ページ数 | 6 |
| ジャーナル | Immunology Letters |
| 巻 | 31 |
| 号 | 3 |
| DOI | |
| 出版ステータス | Published - 1992 2 15 |
ASJC Scopus subject areas
- 免疫アレルギー学
- 免疫学
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
