Spatial and topological distribution of progesterone receptor A and B isoforms during human development

Tsukasa Inoue, Jun Ichi Akahira, Junji Takeyama, Takashi Suzuki, Andrew D. Darnel, Chika Kaneko, Yoshimochi Kurokawa, Susumu Satomi, Hironobu Sasano

研究成果: Article査読

24 被引用数 (Scopus)

抄録

Progesterone receptor (PR) is a member of the nuclear receptor superfamily. To date, two isoforms of PR have been identified, PR-A and PR-B. In progesterone responsive tissues, the relative ratio of PR-A and PR-B is considered to contribute to the tissue-specific actions of progesterone. In this study, we examined the distribution of PR-A and PR-B in human fetal tissues ranging from 11 to 40 gestational weeks using immunohistochemistry and RT-PCR analysis. PR immunoreactivity was detected in a wide range of fetal tissues until 20 weeks of gestation, but gradually decreased towards the late gestational period. However, PR continued to remain positive throughout the gestational period in the interstitial cells of Cajal and endocrine tissues. PR-B was demonstrated as the predominant isoform in comparison to PR-A in all fetal tissues examined. These findings suggest that progesterone may be involved in the development of fetal organs throughout the gestational period.

本文言語English
ページ(範囲)83-89
ページ数7
ジャーナルMolecular and Cellular Endocrinology
182
1
DOI
出版ステータスPublished - 2001 8 20

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 内分泌学

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