Sonodynamically-induced antitumor effect of mono-1-aspartyl Chlorin e6 (NPe6)

Nagahiko Yumita, Yumiko Iwase, Koji Nishi, Toshihiko Ikeda, Hajime Komatsu, Toshio Fukai, Kenji Onodera, Hiroyoshi Nishi, Kazuyoshi Takeda, Shin Ichiro Umemura, Kazuho Okudaira, Yasunori Momose

研究成果: Article査読

22 被引用数 (Scopus)


Background: The sonodynamically-induced in vitro and in vivo antitumor effects of mono-l-aspartyl chlorin e6 (NPe6) was investigated. Materials and Methods: Both in vitro and in vivo antitumor effects were tested in combination with ultrasound at 2 MHz. Results: The rate of ultrasonically-induced damage on isolated sarcoma 180 cells in air-saturated suspension was enhanced two-fold with 80 μM NPe6. The co-administration of 25 mg/kg NPe6 followed by ultrasonic exposure at 2 MHz suppressed the growth of implanted colon 26 cell tumors at an intensity at which ultrasound alone showed only a slight antitumor effect. Conclusion: These in vitro and in vivo results suggest that NPe6 is a potential sensitizer for sonodynamic tumor treatment. The enhancement of cell damage by NPe6 was significantly inhibited by histidine, which may suggest reactive oxygen species plays a primary role in sonodynamically-induced antitumor effect.

ジャーナルAnticancer research
出版ステータスPublished - 2011 2月

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究


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