Sonodynamically-induced anticancer effects by functionalized fullerenes

Nagahiko Yumita, Yumiko Iwase, Takahiro Imaizumi, Ai Sakurazawa, Yuuka Kaya, Koji Nishi, Toshihiko Ikeda, Shin Ichiro Umemura, Fu Shih Chen, Yasunori Momose

研究成果: Article査読

26 被引用数 (Scopus)


Background: Functionalized fullerenes, such as polyhydroxy fullerenes (PHF), have attracted particular attention due to their water solubility and their potential application in tumor imaging and therapy as carbon nanomaterials. In this study, the sonodynamically-induced antitumor effect of PHF was investigated. Materials and Methods: Sonodynamically-induced antitumor effects of PHF in combination with ultrasound were investigated using isolated sarcoma 180 cells and solid tumor from colon 26 carcinoma cells. Results: The cell damage induced by sonication was enhanced by two-fold in the presence of 80 μM PHF. Histidine significantly inhibited this enhancement. This inhibitory effect suggests that the sonodynamicallyinduced antitumor effect was mediated by sonodynamicallygenerated reactive oxygen species. The combined treatment of ultrasonic exposure with PHF suppressed the growth of implanted colon 26 tumors. The destruction of tumor tissue was observed with the ultrasonic treatment in combination with PHF, while neither the treatment with PHF alone nor that with ultrasound alone caused necrosis. Conclusion: These results suggest that PHF is a potential sonosensitizer for sonodynamic treatment of solid tumors.

ジャーナルAnticancer research
出版ステータスPublished - 2013 8月

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究


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