Sonodynamic Therapy: Advances and Challenges in Clinical Translation

Maxime Lafond, Shin Yoshizawa, Shin ichiro Umemura

研究成果: Review article査読

34 被引用数 (Scopus)

抄録

Sonodynamic therapy (SDT) consists of the synergetic interaction between ultrasound and a chemical agent. In SDT, the cytotoxicity is triggered by ultrasonic stimuli, notably through cavitation. The unique features of SDT are relevant in the clinical context more than ever: the need for efficacy, accuracy, and safety while being noninvasive and preserving the patient's quality of life. However, despite the promising results of this technique, only a few clinical reports describe the use of SDT. The objective of this article is to provide an extensive overview of the clinical and preclinical research conducted in vivo on SDT, to identify the limitations, and to detail the developed strategies to overcome them.

本文言語English
ページ(範囲)567-580
ページ数14
ジャーナルJournal of Ultrasound in Medicine
38
3
DOI
出版ステータスPublished - 2019 3

ASJC Scopus subject areas

  • 放射線技術および超音波技術
  • 放射線学、核医学およびイメージング

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