Solid-phase syntheses of olefin-containing inhibitors for HTLV-1 protease using the Horner-Emmons reaction

Jeong Kyu Bang, Hiromi Naka, Kenta Teruya, Saburo Aimoto, Hiroyuki Konno, Kazuto Nosaka, Tadashi Tatsumi, Kenichi Akaji

研究成果: Article査読

10 被引用数 (Scopus)

抄録

The solid-phase Horner-Emmons reaction was successfully applied for the convenient syntheses of olefin-containing protease inhibitors. The isomerization during the solid-phase Horner-Emmons reaction can be minimized simply by the use of an appropriate amount of the base. The synthesized olefin peptides, which have an olefin γ-amino acid at the scissile site, were found to act as effective inhibitors for the HTLV-1 protease for the first time.

本文言語English
ページ(範囲)10596-10599
ページ数4
ジャーナルJournal of Organic Chemistry
70
25
DOI
出版ステータスPublished - 2005 12月 9
外部発表はい

ASJC Scopus subject areas

  • 有機化学

フィンガープリント

「Solid-phase syntheses of olefin-containing inhibitors for HTLV-1 protease using the Horner-Emmons reaction」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル