Small molecule inhibitors of peptidylprolyl cis/trans isomerase

Tadashi Mori, Takafumi Uchida

研究成果: Review article査読

5 被引用数 (Scopus)

抄録

We would like to review the recent study of the inhibitors for peptidyl-prolyl cis/trans isomerase (PPIase), such as cyclophilin (Cyp), FK506- binding protein (FKBP) and Pin1. The inhibitors of Cyp and FKBP, CsA and FK506 respectively are well known potent immunosuppressive drugs. However, they cause a variety of side- effects. Therefore efforts are under way to identify PPIase inhibitors with less side- effects. In this review, efforts of discovering small molecule inhibitors are emphasized. While Cyp and FKBP inhibitors have been explored fairly thoroughly, the number of efforts to screen inhibitors of Pin1 is still limited so far. We think that the inhibitor of Pin1 has high potential as a drug.

本文言語English
ページ(範囲)46-53
ページ数8
ジャーナルCurrent Enzyme Inhibition
6
1
DOI
出版ステータスPublished - 2010 2 1

ASJC Scopus subject areas

  • 生化学
  • 分子医療
  • 創薬

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