A 61-year-old male visited us with chief complaints of macroscopic hematuria and bladder irritation symptons. Cystoscope, U/S, MRI, and CT showed an extensive non-papillary, wide-based tumor centering around the anterior wall of the bladder. Transabdominal U/S-guided full-thickness biopsy indicated a pT3a (Biopsy) primary small cell carcinoma of the bladder containing neuroendocrine granules. Immunohistochemical studies revealed Fuc GM1, an antigen related to small cell carcinoma of the lung. Neoadjuvant therapy consisted of preoperative irradiation at 50 Gy and intraarteial infusion chemotherapy with CDDP and THP. Since a follow-up full thickness biopsy indicated pTO (Biopsy), total cystectomy was performed. Examination of the resected specimen also indicated pathological CR.
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