Skeletal muscle tissue improvement by co-culture system in gelatin methacrylate hydrogel

S. Ostrovidov, S. Ahadian, H. Kaji, M. Ramalingam, A. Khademhosseini

研究成果: Conference contribution

抄録

In this study, we demonstrate that a co-culture approach between C2C12 myoblasts and pheochromocytoma PC12 neuronal cells allows for better formation of muscle-like tissues than a mono-culture of C2C12 cells. In particular, we used a micromolding technique to fabricate microgrooved patterns of methacrylated gelatin (GelMA) hydrogel, which served as a substrate to culture encapsulated cells in GelMA and to induce myoblasts alignment. GelMA is a semi-natural polymer that is easy to pattern by UV irradiation for making 3D structures in which cells can proliferate. Myoblasts and the resulting myotubes were analyzed in terms of alignment and length, respectively, in the mono-culture and the co-culture systems for both patterned and unpatterned regions.

本文言語English
ホスト出版物のタイトルProceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
出版社Chemical and Biological Microsystems Society
ページ1135-1137
ページ数3
ISBN(印刷版)9780979806452
出版ステータスPublished - 2012
イベント16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012 - Okinawa, Japan
継続期間: 2012 10月 282012 11月 1

出版物シリーズ

名前Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012

Other

Other16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012
国/地域Japan
CityOkinawa
Period12/10/2812/11/1

ASJC Scopus subject areas

  • 化学工学(その他)
  • バイオエンジニアリング

フィンガープリント

「Skeletal muscle tissue improvement by co-culture system in gelatin methacrylate hydrogel」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル