Site-specific phosphorylation of Tau protein is associated with deacetylation of microtubules in mouse spermatogenic cells during meiosis

Hiroki Inoue, Yuuki Hiradate, Yoshiki Shirakata, Kenta Kanai, Keita Kosaka, Aina Gotoh, Yasuhiro Fukuda, Yutaka Nakai, Takafumi Uchida, Eimei Sato, Kentaro Tanemura

研究成果: Article査読

11 被引用数 (Scopus)

抄録

Tau is one of the microtubule-associated proteins and a major component of paired helical filaments, a hallmark of Alzheimer's disease. Its expression has also been indicated in the testis. However, its function and modification in the testis have not been established. Here, we analyzed the dynamics of phosphorylation patterns during spermatogenesis. The expression of Tau protein and its phosphorylation were shown in the mouse testis. Immunohistochemistry revealed that the phosphorylation was strongly detected during meiosis. Correspondingly, the expression of acetylated tubulin was inversely weakened during meiosis. These results suggest that phosphorylation of Tau protein contributes to spermatogenesis, especially in meiosis.

本文言語English
ページ(範囲)2003-2008
ページ数6
ジャーナルFEBS Letters
588
11
DOI
出版ステータスPublished - 2014 5 29

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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