Single Dose Radiocurability of Four Murine Solid Tumors and a Predictive Assay for the Curability in situ

Yoshihiro Takai, Yosio Hosoi, Kiyohiko Sakamoto, Sigefumi Okada

研究成果: Article査読

抄録

Correlations between radiocurability and kinetic parameters were investigated in tour transplantable tumor types in WHT/Ht mice. The radiation dose to achieve 50% tumor control at 120 days after irradiation, i.e., TCD50/120, was 30 Gy for squamous cell carcinoma H, 32 Gy for squamous cell carcinoma NOS, 46 Gy for rhabdomyosarcoma KAS, and 63 Gy for fibrosarcoma YAS. The tumor cell kinetic parameters investigated were specific growth delay, volume doubling time, 125I-iododeoxyuridine (IUdR) uptake rate, and specific cell loss rate. The specific cell loss rate was defined as the ratio of cell loss rate in non-irradiated tumors to the rate in irradiated tumors, and was obtained by measuring the retention rate of radioactivity in the tumors. No correlations were found between specific growth delay, volume doubling time, 125I-IUdR uptake rate, andTCD50. However, the specific cell loss rate correlated with the TCD50. Therefore, the 125I-IUdR labeling method may be useful as an in situ predictive assay for tumor radiocurability.

本文言語English
ページ(範囲)233-240
ページ数8
ジャーナルJournal of radiation research
38
4
DOI
出版ステータスPublished - 1997 12月

ASJC Scopus subject areas

  • 放射線
  • 放射線学、核医学およびイメージング
  • 健康、毒物学および変異誘発

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