Single-arm confirmatory trial of postoperative concurrent chemoradiotherapy using intensity modulated radiation therapy for patients with high-risk uterine cervical cancer: Japan Clinical Oncology Group study (JCOG1402)

Naoya Murakami, Fumiaki Isohashi, Yoko Hasumi, Takahiro Kasamatsu, Hiroyuki Okamoto, Kenichi Nakamura, Taro Shibata, Yoshinori Ito, Satoshi Ishikura, Yasumasa Nishimura, Nobuo Yaegashi, Takafumi Toita

研究成果: Article査読

2 被引用数 (Scopus)

抄録

A single-arm multi-center confirmatory trial was started in Japan to confirm the efficacy and safety of post-radical hysterectomy concurrent chemoradiotherapy using intensity-modulated radiation therapy (IMRT-CCRT) for patients with high-risk uterine cervical cancer, for which the current standard treatment is CCRT using three-dimensional conformal radiation therapy (3DCRT-CCRT). This study began in April 2017 and a total of 220 patients will be accrued from 44 institutions within 3.5 years. The primary endpoint is 3-year relapse-free survival. The secondary endpoints are overall survival, loco-regional relapse-free survival, proportion of late lower gastrointestinal adverse events greater than or equal to grade 3, proportion of lower edema limbs, adverse events, and serious adverse events. This trial was registered at the Japan Registry of Clinical Trials as jRCTs031180194 (https://jrct.niph.go.jp/).

本文言語English
ページ(範囲)881-885
ページ数5
ジャーナルJapanese journal of clinical oncology
49
9
DOI
出版ステータスPublished - 2019 10月 15

ASJC Scopus subject areas

  • 腫瘍学
  • 放射線学、核医学およびイメージング
  • 癌研究

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