Measurements of the oxygen consumption in brain have been studied by PET. Autoradiographic method (ARG) was suggested (Mintum et al.) to yield CMRO 2. This method required separately obtained information about CBF, CBV, thus time of 30-60 min. is required for three separate scans. To decrease the scan time, a new protocol was suggested as a rapid dual table method (ARG-D), in which [15O]water injection scan and [ 15O]O2 inhalation scan are continuously carried out. Another method of weighted integration(WI) method with single 3 min. 15O2 inhalation scan was suggested (Ohta et al.). We modified this method by taking into account the water re-circulation(WI-WR). In this study, the statistical noise properties and effects of error propagated from dispersion, delay, and volume of distribution on CMRO2 image, derived by these methods were evaluated. Tissue time activity curves was generated from typical blood time activity curves. A 80 % of noise at a peak in [15O] water tissue time acticity curve was added to study the noise propagation and accuracy in CMRO2 image. Also dispersion, delay, and volume of distribution was varied and evaluated the error propagation. Methods of ARG, WI-WR and ARG-D, reproduce the given CMRO2 within 2% accuracy, while method WI gives CMRO2 5-15 The effect of noise in unit of %SD was 12 % for ARG, 25 % for WI and WI-WR, and 17 % for ARG-D method. On the basis of simulation study suggests that the ARG-D method developed could be used to estimate the CMRO2 values in clinic.
|出版ステータス||Published - 2002|
|イベント||2002 IEEE Nuclear Science Symposium Conference Record - Norfolk, VA, United States|
継続期間: 2002 11 10 → 2002 11 16
|Other||2002 IEEE Nuclear Science Symposium Conference Record|
|Period||02/11/10 → 02/11/16|
ASJC Scopus subject areas