Simulated microgravity does not alter epithelial cell adhesion to matrix and other molecules

J. M. Jessup, K. Brown, S. Ishii, R. Ford, T. J. Goodwin, G. Spaulding

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Microgravity has advantages for the cultivation of tissues with high fidelity; however, tissue formation requires cellular recognition and adhesion. We tested the hypothesis that simulated microgravity does not affect cell adhesion. Human colorectal carcinoma cells were cultured in the NASA Rotating Wall Vessel (RWV) under low shear stress with randomization of the gravity vector that simulates microgravity. After 6 - 7 days, cells were assayed for binding to various substrates and compared to cells grown in standard tissue culture flasks and static suspension cultures. The RWV cultures bound as well to basement membrane proteins and to CEA, an intercellular adhesion molecule, as control cultures did. Thus, microgravity does not alter epithelial cell adhesion and may be useful for tissue engineering.

本文言語English
ページ(範囲)71-76
ページ数6
ジャーナルAdvances in Space Research
14
8
DOI
出版ステータスPublished - 1994 8
外部発表はい

ASJC Scopus subject areas

  • 航空宇宙工学
  • 天文学と天体物理学
  • 地球物理学
  • 大気科学
  • 宇宙惑星科学
  • 地球惑星科学(全般)

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