Significant correlation between IL-10 levels and IgG indices in the cerebrospinal fluid of patients with multiple sclerosis

Ichiro Nakashima, Kazuo Fujihara, Tatsuro Misu, Naoshi Okita, Sadao Takase, Yasuto Itoyama

研究成果: Article査読

30 被引用数 (Scopus)

抄録

We measured the interleukin (IL)-6 and IL-10 levels in the plasma and the cerebrospinal fluid (CSF) of a total of 23 relapsing multiple sclerosis (MS) patients [18 with conventional form of MS (C-MS) and 5 with optic-spinal form of MS (OS-MS)] using ELISA and correlated them with the IgG indices and oligoclonal IgG bands (OB) to determine whether these cytokines play a role in the intrathecal immunoglobulin production. IL-10 values in the CSF significantly correlated with the IgG indices and tended to be higher in OB-positive patients. In contrast, IL-10 values in the plasma and IL-6 values in the CSF and the plasma did not correlate with the IgG indices or OB. The CSF-IL-10 value in OS-MS were much lower than those of C-MS, but those of CSF IL-6 did not differ between C-MS and OS-MS. The results remained unchanged even when OS-MS patients were excluded. Our results may suggest a role of IL-10 in upregulating the intrathecal IgG synthesis in relapsing MS. Copyright (C) 2000 Elsevier Science B.V.

本文言語English
ページ(範囲)64-67
ページ数4
ジャーナルJournal of Neuroimmunology
111
1-2
DOI
出版ステータスPublished - 2000 11 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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