The secordary infection of the lung in association with lung cancer was found in 152 of 405 cases (37%). The secondary infection was found in 47 of 152 cases at the time of admission. In most cases the secondary infection resulted from narrowing of the large bronchi. Gram-negative bacteria, especially klebsiella pneumoniae were found frequently in sputum. There was a tendency for those who showed weakly positive tuberculin reaction to be susceptible to secondary infections. The level of serum albumin in these cases tended to become lower after infection. Leucopenia and treatment with steroid hormons were the major predisposing factors of the secondary infections. The prognosis was very poor in those cases with leucopenia of below 3,000. The pulmonary infection was the direct cause of death in 22% of the cases, the diagnosis of which were verified at autopsy. The response to treatment with anti-cancer drugs was unsatisfactory secondary infections occurred. In order to prevent the occurrence of secondary infections, it is recommended to avoid the administration for extended preiods of a large dosis of steroid hormons and to exercise due caution to the number of leucocytes.
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