Significance of lutein in red blood cells of Alzheimer's disease patients

Takehiro Kiko, Kiyotaka Nakagawa, Tsuyoshi Tsuduki, Toshihide Suzuki, Hiroyuki Arai, Teruo Miyazawa

研究成果: Article査読

39 被引用数 (Scopus)

抄録

Red blood cells (RBC) of Alzheimer's disease (AD) patients are known to be in an excessively oxidized state (i.e., with a high accumulation of peroxidized phospholipids (PLOOH)). Previously we confirmed in vitro, in vivo murine, and in human studies that carotenoids can effectively inhibit accumulation of RBC PLOOH. Thus, the relationship between RBC carotenoids and PLOOH concentrations in AD patients is of interest. In this study, RBC carotenoids and PLOOH were evaluated in 28 normal control subjects (age: 74.1 ± 1.3 years) and 28 patients with AD (age: 72.5 ± 1.4 years). The concentrations of RBC carotenoids, especially lutein, in AD patients were significantly lower than in control subjects. An inverse relationship was seen between RBC carotenoids, especially lutein, and PLOOH concentrations in AD patients. These results suggest that RBC lutein, in particular, may contribute to suppression of PLOOH accumulation in RBC of AD patients.

本文言語English
ページ(範囲)593-600
ページ数8
ジャーナルJournal of Alzheimer's Disease
28
3
DOI
出版ステータスPublished - 2012

ASJC Scopus subject areas

  • 神経科学(全般)
  • 臨床心理学
  • 老年医学
  • 精神医学および精神衛生

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