Signaling pathways for stress responses and adaptation in Aspergillus species: Stress biology in the post-genomic era

Daisuke Hagiwara, Kazutoshi Sakamoto, Keietsu Abe, Katsuya Gomi

研究成果: Review article査読

32 被引用数 (Scopus)

抄録

Aspergillus species are among the most important filamentous fungi in terms of industrial use and because of their pathogenic or toxin-producing features. The genomes of several Aspergillus species have become publicly available in this decade, and genomic analyses have contributed to an integrated understanding of fungal biology. Stress responses and adaptation mechanisms have been intensively investigated using the accessible genome infrastructure. Mitogen-activated protein kinase (MAPK) cascades have been highlighted as being fundamentally important in fungal adaptation to a wide range of stress conditions. Reverse genetics analyses have uncovered the roles of MAPK pathways in osmotic stress, cell wall stress, development, secondary metabolite production, and conidia stress resistance. This review summarizes the current knowledge on the stress biology of Aspergillus species, illuminating what we have learned from the genomic data in this "post-genomic era."

本文言語English
ページ(範囲)1667-1680
ページ数14
ジャーナルBioscience, Biotechnology and Biochemistry
80
9
DOI
出版ステータスPublished - 2016

ASJC Scopus subject areas

  • バイオテクノロジー
  • 分析化学
  • 生化学
  • 応用微生物学とバイオテクノロジー
  • 分子生物学
  • 有機化学

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