Signal pathway analysis with differentiation markers in osteoblasts stimulated by synthetic analogue to bone mineral

Ryuhei Nishikawa, Takahisa Anada, Osamu Suzuki

研究成果: Conference contribution

抄録

OCTACALCIUM PHOSPHATE (Ca8H2(PO4) 6·5H2O; OCP) is considered as a precursor of biological apatite crystals in bone and tooth in vertebrates. Recent studies have suggested that osteoblastic cell differentiation is enhanced in contact with OCP which is converted into HA and is significantly facilitated in an OCP dose-dependent manner. MAPK signaling is known to be activated in the early stage of the differentiation from bone marrow-derived mesenchymal stem cells into osteoblasts. However, the MAPK signaling is unclear in relation to the stimulatory capacity of OCP in the osteoblastic differentiation. In this study, we investigated the MAPK signaling during the differentiation of bone marrow-derived stromal cell line leading to the late differentiation stage using gene expression analysis.

本文言語English
ホスト出版物のタイトル2012 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2012
ページ164-168
ページ数5
DOI
出版ステータスPublished - 2012 12 1
イベント23rd Annual Symposium on Micro-Nano Mechatronics and Human Science, MHS 2012 - Nagoya, Japan
継続期間: 2012 11 42012 11 7

出版物シリーズ

名前2012 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2012

Other

Other23rd Annual Symposium on Micro-Nano Mechatronics and Human Science, MHS 2012
CountryJapan
CityNagoya
Period12/11/412/11/7

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering

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