Shortened telomere length in hepatocellular carcinomas and corresponding background liver tissues of patients infected with hepatitis virus

Kazuo Ohashi, Masahiro Tsutsumi, Kunihiko Kobitsu, Tomokazu Fukuda, Toshifumi Tsujiuchi, Eijiro Okajima, Saiho Ko, Yoshiyuki Nakajima, Hiroshige Nakano, Yoichi Konishi

研究成果: Article査読

15 被引用数 (Scopus)

抄録

The telomere length in 20 surgically resected human hepatocellular carcinomas (HCCs) and adjacent non-cancerous livers with hepatitis virus infection were investigated. All the HCC samples examined demonstrated shorter telomere length than the corresponding non-cancerous liver tissues, the respective average values being 5.4 kbp and 8.8 kbp (P < 0.001). The shortening of telomere length was most prominent in HCCs larger than 30 mm in diameter, and in both tumors and non-cancerous livers it was more marked with hepatitis B virus as compared with hepatitis C virus infection. These results indicate that telomere shortening is associated with not only progression, but also development of HCC, and there is a possible difference in the nature of the association in patients with hepatitis viruses of B and C types.

本文言語English
ページ(範囲)419-422
ページ数4
ジャーナルJapanese Journal of Cancer Research
87
5
DOI
出版ステータスPublished - 1996 5

ASJC Scopus subject areas

  • 腫瘍学
  • 癌研究

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