Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex

Yutaka Kimura, Toshikazu Takeshita, Motonari Kondo, Naoto Ishii, Masataka Nakamura, Jacques Van Snick, Kazuo Sugamura

研究成果: Article査読

193 被引用数 (Scopus)

抄録

The third subunit, the so-called common γ (γc) chain, of the IL-2 receptor is shared among the receptors for IL-2, IL-4, IL-7 and IL-15, and dysfunction of the γc chain is thought to cause X-linked severe combined immunodeficiency (XSCID) ascribed to impairment of early T cell development. However, cytokines linked to XSCID are as yet unidentified. A mAb specific for the γc chain, TUGm2, profoundly inhibited cell proliferation in response to IL-9. Another mAb, TUGm3, immunoprecipltated [125I]IL-9 cross-linked with either the IL-9 receptor or the γc chain. These results demonstrate that the γc chain is included in the functional receptor complex for IL-9, which was initially characterized as a T cell growth factor and is essential for IL-9-dependent growth signal transductlon.

本文言語English
ページ(範囲)115-120
ページ数6
ジャーナルInternational immunology
7
1
DOI
出版ステータスPublished - 1995 1月

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学

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