Shape sensitivity on toxicity of gold nanoplates in breast cancer cells

Chunyan Wang, Yoshikazu Ito, Bindu Pradeep, Suresh Valiyaveettil

    研究成果: Article査読

    2 被引用数 (Scopus)

    抄録

    Gold nanomaterials (Au NMs) have been explored for a wide range of applications in catalysis and medicine. Here we report the shape sensitive toxicity of gold nanoplates (Au nanoplates) in breast cancer cell line, MCF7. Au nanoplates induced a dose- and shape-dependent toxicity to cancer cells. Oxidative stress induced by Au nanoplates is believed to be the trigger for the DNA, which resulted in cell apoptosis. In summary, the results from our study demonstrate that morphology appears to play a significant role in mediating the cellular responses and Au triangles nanoplates showed the highest toxicity to the cells. Such findings may be able to shine more light on the shape-dependent interaction between Au NMs and living organisms.

    本文言語English
    ページ(範囲)9520-9530
    ページ数11
    ジャーナルJournal of Nanoscience and Nanotechnology
    15
    12
    DOI
    出版ステータスPublished - 2015 12 1

    ASJC Scopus subject areas

    • バイオエンジニアリング
    • 化学 (全般)
    • 生体医工学
    • 材料科学(全般)
    • 凝縮系物理学

    フィンガープリント

    「Shape sensitivity on toxicity of gold nanoplates in breast cancer cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル