TY - JOUR
T1 - Sex steroid metabolism and actions in non-small cell lung carcinoma
AU - Asavasupreechar, Teeranut
AU - Chan, Monica S.M.
AU - Saito, Ryoko
AU - Miki, Yasuhiro
AU - Boonyaratanakornkit, Viroj
AU - Sasano, Hironobu
PY - 2019/10
Y1 - 2019/10
N2 - Despite recent development in targeted therapies, lung cancer still remains the leading cause of cancer death. Therefore, a better understanding of its pathogenesis and progression could contribute to improving the eventual clinical outcome of the patients. Results of recently published several in vitro and clinical studies indicated the possible involvement of sex steroids in both development and progression of non-small cell lung carcinoma (NSCLC). Therefore we summarized the reported clinical relevant information of the sex steroids, their receptors and steroid metabolizing enzymes related to NSCLC in this mini-review. In addition, we also reviewed the potential “endocrine therapy”, targeting sex steroid actions and/or metabolism in NSCLC patients.
AB - Despite recent development in targeted therapies, lung cancer still remains the leading cause of cancer death. Therefore, a better understanding of its pathogenesis and progression could contribute to improving the eventual clinical outcome of the patients. Results of recently published several in vitro and clinical studies indicated the possible involvement of sex steroids in both development and progression of non-small cell lung carcinoma (NSCLC). Therefore we summarized the reported clinical relevant information of the sex steroids, their receptors and steroid metabolizing enzymes related to NSCLC in this mini-review. In addition, we also reviewed the potential “endocrine therapy”, targeting sex steroid actions and/or metabolism in NSCLC patients.
KW - Lung
KW - Lung cancer treatment
KW - Non-small cell lung carcinoma
KW - Sex steroid receptors
KW - Sex steroids
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U2 - 10.1016/j.jsbmb.2019.105440
DO - 10.1016/j.jsbmb.2019.105440
M3 - Review article
C2 - 31386890
AN - SCOPUS:85070782750
VL - 193
JO - Journal of Steroid Biochemistry
JF - Journal of Steroid Biochemistry
SN - 0960-0760
M1 - 105440
ER -