Sex steroid metabolism and actions in non-small cell lung carcinoma

Teeranut Asavasupreechar, Monica S.M. Chan, Ryoko Saito, Yasuhiro Miki, Viroj Boonyaratanakornkit, Hironobu Sasano

研究成果: Review article査読

3 被引用数 (Scopus)

抄録

Despite recent development in targeted therapies, lung cancer still remains the leading cause of cancer death. Therefore, a better understanding of its pathogenesis and progression could contribute to improving the eventual clinical outcome of the patients. Results of recently published several in vitro and clinical studies indicated the possible involvement of sex steroids in both development and progression of non-small cell lung carcinoma (NSCLC). Therefore we summarized the reported clinical relevant information of the sex steroids, their receptors and steroid metabolizing enzymes related to NSCLC in this mini-review. In addition, we also reviewed the potential “endocrine therapy”, targeting sex steroid actions and/or metabolism in NSCLC patients.

本文言語English
論文番号105440
ジャーナルJournal of Steroid Biochemistry and Molecular Biology
193
DOI
出版ステータスPublished - 2019 10

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 生化学
  • 分子医療
  • 分子生物学
  • 内分泌学
  • 臨床生化学
  • 細胞生物学

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