Severe diastolic dysfunction with preserved energy conversion efficiency after countershock

Satoshi Yasuda, Toshiaki Shishido, Yoichi Goto

研究成果: Article査読

5 被引用数 (Scopus)

抄録

The left ventricular (LV) mechanical performance and the LV myocardial oxygen consumption (V̇O2)-to-pressure-volume area (PVA; LV total mechanical energy index) relationship were measured in isovolumic contraction of isolated blood-perfused dog hearts before and after direct current (DC) countershocks. At a constant LV volume, DC shocks increased LV end-diastolic pressure progressively and strikingly with the progression of myocardial edema and a marked prolongation of the time constant of LV pressure decay. In contrast, DC shocks changed neither the slope of the LV end-systolic pressure-volume relationship nor the contractile efficiency (the slope of the V̇O2-PVA relationship). The oxygen cost of contractility (the slope of the relationship between PVA-independent V̇O2 and LV contractility) increased 27% after DC shocks. However, the magnitude of this change was considerably smaller than that previously reported in postischemic stunned myocardium (123%), suggesting that the adverse effect of DC shocks on the energy cost of excitation-contraction coupling is relatively minor. Thus, despite the severe diastolic dysfunction, DC shocks do not substantially impair either the efficiency of cross-bridge cycling or calcium cycling. Myocardial interstitial edema is more likely a potential mechanism of diastolic dysfunction after DC shocks.

本文言語English
ページ(範囲)H583-H592
ジャーナルAmerican Journal of Physiology - Heart and Circulatory Physiology
273
2 42-2
DOI
出版ステータスPublished - 1997
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 循環器および心血管医学
  • 生理学(医学)

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