TY - JOUR
T1 - Serum autotaxin measurement in haematological malignancies
T2 - A promising marker for follicular lymphoma
AU - Masuda, Akiko
AU - Nakamura, Kazuhiro
AU - Izutsu, Koji
AU - Igarashi, Koji
AU - Ohkawa, Ryunosuke
AU - Jona, Masahiro
AU - Higashi, Katsumi
AU - Yokota, Hiromitsu
AU - Okudaira, Shinichi
AU - Kishimoto, Tatsuya
AU - Watanabe, Takuro
AU - Koike, Yukako
AU - Ikeda, Hitoshi
AU - Kozai, Yasushi
AU - Kurokawa, Mineo
AU - Aoki, Junken
AU - Yatomi, Yutaka
PY - 2008/10
Y1 - 2008/10
N2 - Autotaxin (ATX) is a tumour cell motility-stimulating factor originally isolated from melanoma cell supernatants. ATX is identical to lysophospholipase D, which produces a bioactive lipid mediator, lysophosphatidic acid (LPA), from lysophosphatidylcholine. ATX is overexpressed in various malignancies, including Hodgkin lymphoma, and ATX may stimulate tumour progression via LPA production. The present study measured the serum ATX antigen levels in patients with haematological malignancies using a recently developed automated enzyme immunoassay. The serum ATX antigen levels in patients with B-cell neoplasms, especially follicular lymphoma (FL), were higher than those in healthy subjects. Serum ATX antigen levels in FL patients were associated with tumour burden and changed in parallel with the patients' clinical courses. The serum ATX antigen levels were little affected by inflammation, unlike the soluble interleukin-2 receptor and β2-microglobulin levels. As expected, the plasma LPA levels in FL patients were correlated with the serum ATX antigen levels. Given that leukaemic tumour cells from FL patients expressed ATX, the shedding of ATX from lymphoma cells probably leads to the elevation of serum ATX antigen levels. Our results suggest that the serum ATX antigen level may be a promising and novel marker for FL.
AB - Autotaxin (ATX) is a tumour cell motility-stimulating factor originally isolated from melanoma cell supernatants. ATX is identical to lysophospholipase D, which produces a bioactive lipid mediator, lysophosphatidic acid (LPA), from lysophosphatidylcholine. ATX is overexpressed in various malignancies, including Hodgkin lymphoma, and ATX may stimulate tumour progression via LPA production. The present study measured the serum ATX antigen levels in patients with haematological malignancies using a recently developed automated enzyme immunoassay. The serum ATX antigen levels in patients with B-cell neoplasms, especially follicular lymphoma (FL), were higher than those in healthy subjects. Serum ATX antigen levels in FL patients were associated with tumour burden and changed in parallel with the patients' clinical courses. The serum ATX antigen levels were little affected by inflammation, unlike the soluble interleukin-2 receptor and β2-microglobulin levels. As expected, the plasma LPA levels in FL patients were correlated with the serum ATX antigen levels. Given that leukaemic tumour cells from FL patients expressed ATX, the shedding of ATX from lymphoma cells probably leads to the elevation of serum ATX antigen levels. Our results suggest that the serum ATX antigen level may be a promising and novel marker for FL.
KW - Autotaxin
KW - Follicular lymphoma
KW - Lysophosphatidic acid
KW - Lysophospholipase D
KW - Lysophospholipid
UR - http://www.scopus.com/inward/record.url?scp=51249116856&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=51249116856&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2141.2008.07325.x
DO - 10.1111/j.1365-2141.2008.07325.x
M3 - Article
C2 - 18710386
AN - SCOPUS:51249116856
VL - 143
SP - 60
EP - 70
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 1
ER -