Carrier-free drug nanoparticles are emerging as a next generation of drug delivery systems. Herein, we worked on improving their dispersion stability in the physiological environment by employing serum albumin protein. With anticancer SN-38 prodrug nanoparticles (NPs) and bovine serum albumin (BSA) as model studies, it was found that BSA prevented SN-38 NPs from aggregating in phosphate buffered saline, and the resulted nanoparticle dispersion becomes stable while maintains their anticancer efficiency.
ASJC Scopus subject areas
- 化学 (全般)