TY - JOUR
T1 - Serum β2-microglobulin concentration and its removal in patients treated with continuous ambulatory peritoneal dialysis
AU - Kubo, Hitoshi
AU - Kawaguchi, Yoshindo
AU - Aizawa, Sumio
AU - Morita, Takashi
AU - Nakayama, Masaaki
AU - Wakabayashi, Yoshinori
AU - Watanabe, Shuuichi
AU - Ogawa, Aiichirou
AU - Sakai, Osamu
PY - 1990/1
Y1 - 1990/1
N2 - This study was performed to clarify serum beta-2 microglobulin (β2-M) level and its change in 50 CAPD and 56 HD patients. There was significant correlation between duration of dialysis and serum β2-M level in CAPD and HD patients treated under 12 months, but no correlation in those treated over 12 months. Serum β2-M level was 33.5±9.1 mg/1 in 45 CAPD patients treated over 12 months, and 46.2±21.1 mg/1 m 35 HD patients. In 26 CAPD patients treated over 12 months, clearance and removal of β2-M were 1.0±0.3ml/min and 43.0±17.8 mg/day. There was significant correlation between dwell time and β2-M removal (p<0.01), and these results suggested β2-M was removed by diffusion. Because CAPD treatment can lower serum β2-M level compared to HD, there is possibility that CAPD is useful at prevention of dialysis associated amyloidosis.
AB - This study was performed to clarify serum beta-2 microglobulin (β2-M) level and its change in 50 CAPD and 56 HD patients. There was significant correlation between duration of dialysis and serum β2-M level in CAPD and HD patients treated under 12 months, but no correlation in those treated over 12 months. Serum β2-M level was 33.5±9.1 mg/1 in 45 CAPD patients treated over 12 months, and 46.2±21.1 mg/1 m 35 HD patients. In 26 CAPD patients treated over 12 months, clearance and removal of β2-M were 1.0±0.3ml/min and 43.0±17.8 mg/day. There was significant correlation between dwell time and β2-M removal (p<0.01), and these results suggested β2-M was removed by diffusion. Because CAPD treatment can lower serum β2-M level compared to HD, there is possibility that CAPD is useful at prevention of dialysis associated amyloidosis.
KW - CAPD
KW - amyloidosis
KW - β2-microglobulin
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U2 - 10.14842/jpnjnephrol1959.32.419
DO - 10.14842/jpnjnephrol1959.32.419
M3 - Article
C2 - 2198365
AN - SCOPUS:0025408535
VL - 32
SP - 419
EP - 426
JO - Japanese Journal of Nephrology
JF - Japanese Journal of Nephrology
SN - 0385-2385
IS - 4
ER -