Seroprevalence of anti-Borrelia antibodies among patients with confirmed sarcoidosis in a region of Japan where Lyme borreliosis is endemic

Mami Ishihara, Shigeaki Ohno, Hiromitsu Ono, Emiko Isogai, Koh'ichi Kimura, Hiroshi Isogai, Koki Aoki, Takako Ishida, Katsuya Suzuki, Satoshi Kotake, Youmei Hiraga

研究成果: Article査読

23 被引用数 (Scopus)

抄録

Background: Sarcoidosis is a multisystemic granulomatous disease of unknown etiology, while Lyme borreliosis is a multisystemic disorder caused by Borrelia burgdorferi. The purpose of this study is to evaluate the relationship between sarcoidosis and Lyme borreliosis in a region of Japan where Lyme borreliosis is endemic. Methods: We determined the seroprevalence of anti-Borrelia burgdorferi antibodies as well as antibodies three Japanese Borrelia strains by enzyme-linked immunosorbent assay and dotblot assay using purified Borrelia-specific proteins in 46 patients with confirmed sarcoidosis and 150 controls (50 disease controls and 100 healthy controls) in Hokkaido, the affected region. Results: Fifteen patients with sarcoidosis (32.6%) tested positive for Borrelia spirochete in both assays, compared with two disease controls (4.0%) and two healthy controls (2.0%). The seroprevalence of anti-Borrelia antibodies in patients with sarcoidosis was much higher in the affected region than in the region in our previous study where Lyme borreliosis is non-endemic. Conclusion: In a region where Lyme borreliosis is endemic, Borrelia infection may be partially associated with sarcoidosis.

本文言語English
ページ(範囲)280-284
ページ数5
ジャーナルGraefe's Archive for Clinical and Experimental Ophthalmology
236
4
DOI
出版ステータスPublished - 1998 4

ASJC Scopus subject areas

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学

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