Sequential expression and role of Hu RNA-binding proteins during neurogenesis

Yoshio Wakamatsu, James A. Weston

研究成果: Article査読

217 被引用数 (Scopus)

抄録

We have identified three avian (chicken) Hu/elav family RNA-binding protein genes. cHuD and cHuC are expressed specifically in neurons of both the central and peripheral nervous systems. Although cHuA is expressed in a wide variety of tissues, including neurogenic precursor cells, it is transiently down-regulated, and is then re-expressed in maturing neurons. Misexpression of cHuD in cultured neural crest cells results in a dramatic increase in the proportion of cells exhibiting neuronal morphology, molecular markers for neurons, and neurotrophin dependence. These data confirm that cHuD protein is involved in regulating neuronal differentiation.

本文言語English
ページ(範囲)3449-3460
ページ数12
ジャーナルDevelopment
124
17
出版ステータスPublished - 1997
外部発表はい

ASJC Scopus subject areas

  • 分子生物学
  • 発生生物学

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