Selenoprotein P as a significant regulator of pancreatic β cell function

研究成果: Review article査読

11 被引用数 (Scopus)

抄録

Selenoprotein P (SeP; encoded by SELENOP) is selenium (Se)-rich plasma protein that is mainly produced in the liver. SeP functions as a Se-transport protein to deliver Se from the liver to other tissues, such as the brain and testis. The protein plays a pivotal role in Se metabolism and antioxidative defense, and it has been identified as a 'hepatokine' that causes insulin resistance in type 2 diabetes. SeP levels are increased in type 2 diabetes patients, and excess SeP impairs insulin signalling, promoting insulin resistance. Furthermore, increased levels of SeP disturb the functioning of pancreatic β cells and inhibit insulin secretion. This review focuses on the biological function of SeP and the molecular mechanisms associated with the adverse effects of excess SeP on pancreatic β cells' function, particularly with respect to redox reactions. Interactions between the liver and pancreas are also discussed.

本文言語English
ページ(範囲)119-124
ページ数6
ジャーナルJournal of Infectious Diseases
220
4
DOI
出版ステータスPublished - 2019 8 15

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 感染症

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