Selective effector coupling of muscarinic acetylcholine receptor subtypes

K. Fukuda, T. Kubo, A. Maeda, I. Akiba, H. Bujo, J. Nakai, M. Mishina, H. Higashida, E. Neher, A. Marty, S. Numa

研究成果: Article査読

36 被引用数 (Scopus)

抄録

Attempts have been made by means of recombinant DNA technology to understand the molecular basis of the functional heterogeneity of the muscarinic acetylcholine receptor (mAChR). Molecularly defined mAChR subtypes have been produced from the cloned DNAs in Xenopus oocytes and NG108-15 neuroblastoma-glioma hybrid cells as transient and stable expression systems, respectively, and agonist-induced cellular responses have been examined. The results obtained provide evidence that mAChR subtypes are selectively coupled with different effector systems, albeit not exclusively.

本文言語English
ページ(範囲)4-10
ページ数7
ジャーナルTrends in Pharmacological Sciences
10
SUPPL.
出版ステータスPublished - 1989 1 1
外部発表はい

ASJC Scopus subject areas

  • 毒物学
  • 薬理学

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