@article{8fa74d8c48ba426ea51d02323c445a1a,
title = "Selective degradation of target proteins by chimeric small-molecular drugs, PROTACs and SNIPERs",
abstract = "New therapeutic modalities are needed to address the problem of pathological but undruggable proteins. One possible approach is the induction of protein degradation by chimeric drugs composed of a ubiquitin ligase (E3) ligand coupled to a ligand for the target protein. This article reviews chimeric drugs that decrease the level of specific proteins such as proteolysis targeting chimeric molecules (PROTACs) and specific and nongenetic inhibitor of apoptosis protein (IAP)-dependent protein erasers (SNIPERs), which target proteins for proteasome-mediated degradation. We cover strategies for increasing the degradation activity induced by small molecules, and their scope for application to undruggable proteins.",
keywords = "Chemical protein degradation, PROTACs, SNIPERs",
author = "Minoru Ishikawa and Shusuke Tomoshige and Yosuke Demizu and Mikihiko Naito",
note = "Funding Information: Funding: The work described in this review article was partially supported by Grants in Aid for Scientific Research from The Ministry of Education, Culture, Sports, Science and Technology, Japan, and the Japan Society for the Promotion of Science (KAKENHI Grant No. 17H03996 (Y.H.), No. 17K19476 (M.I.), and 18H05502 (M.N., Y.D., M.I.)). Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2020",
month = apr,
doi = "10.3390/ph13040074",
language = "English",
volume = "13",
journal = "Pharmaceuticals",
issn = "1424-8247",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "4",
}