Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites

Daiki Morisaki, Hye Sook Kim, Hiroshi Inoue, Hiroki Terauchi, Shusuke Kuge, Akira Naganuma, Yusuke Wataya, Hidetoshi Tokuyama, Masataka Ihara, Kiyosei Takasu

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Fluorescent rhodacyanines, which display antimalarial activity in vitro and in vivo, stain plasmodial parasites at the erythrocytic stage. A good correlation between the antimalarial activity and the accumulation of the dyes is observed. A fused-rhodacyanine, which displays a strong fluorescent property itself, was designed as a new probe for plasmodial parasites. It appears to be specifically localized in the parasitic mitochondria.

本文言語English
ページ(範囲)206-209
ページ数4
ジャーナルChemical Science
1
2
DOI
出版ステータスPublished - 2010 8月

ASJC Scopus subject areas

  • 化学 (全般)

フィンガープリント

「Selective accumulation of rhodacyanine in plasmodial mitochondria is related to the growth inhibition of malaria parasites」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル