Selection for high and low oxygen consumption altered hepatic mitochondrial energy efficiency in mice

Yu Hong, Astrid Ardiyanti, Motoi Kikusato, Tomoyuki Shimazu, Masaaki Toyomizu, Keiichi Suzuki

研究成果: Article査読

6 被引用数 (Scopus)

抄録

Selection for high (H) and low (L) oxygen consumption (OC) as an indirect estimation of maintenance energy requirement was determined. Feed intake and body weight were measured and feed conversion ratio (FCR) of 4-8-week-old mice was calculated. Respiratory activity of hepatic mitochondria was measured at 12 weeks. Total feed intake (H: 103.74g, L: 97.92g, P<0.01), daily feed intake (H: 3.70g/day, L: 3.50g/day, P<0.01) and FCR (H: 18.79, L: 15.50, P<0.01) were significantly different between lines. The line by sex interaction was significant for FCR. No line differences were observed in males; and the FCR of the H line was greater than in the L line in females. H line mice had the highest hepatic mitochondrial respiratory activity in state 2 (P<0.01), the highest uncoupled respiratory rate of mitochondria in the presence of an uncoupling agent (P<0.001), and the mitochondrial proton leak. The adenosine diphosphate/ O ratio was highest in the L line (P<0.05). This suggests that the selection for high and low OC induced differences in basal mitochondrial respiration and basal metabolism, resulting in difference in FCR between H and L lines.

本文言語English
ページ(範囲)818-825
ページ数8
ジャーナルAnimal Science Journal
86
9
DOI
出版ステータスPublished - 2015 9 1

ASJC Scopus subject areas

  • 農業および生物科学(全般)

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