Secretin receptor involvement in prion-infected cells and animals

Tomohiro Kimura, Keiko Nishizawa, Ayumi Oguma, Yuki Nishimura, Yuji Sakasegawa, Kenta Teruya, Ichiko Nishijima, Katsumi Doh-Ura

研究成果: Article査読

2 被引用数 (Scopus)

抄録

Abstract The cellular mechanisms behind prion biosynthesis and metabolism remain unclear. Here we show that secretin signaling via the secretin receptor regulates abnormal prion protein formation in prion-infected cells. Animal studies demonstrate that secretin receptor deficiency slightly, but significantly, prolongs incubation time in female but not male mice. This gender-specificity is consistent with our finding that prion-infected cells are derived from females. Therefore, our results provide initial insights into the reasons why age of disease onset in certain prion diseases is reported to occur slightly earlier in females than males.

本文言語English
論文番号37195
ページ(範囲)2011-2018
ページ数8
ジャーナルFEBS Letters
589
15
DOI
出版ステータスPublished - 2015 7 3

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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