Secretagogue-induced exocytosis recruits G protein-gated K+ channels to plasma membrane in endocrine cells

Ken Ichirou Morishige, Atsushi Inanobe, Yukiko Yoshimoto, Hirohisa Kurachi, Yuji Murata, Yoshimitu Tokunaga, Toshihiro Maeda, Yoshio Maruyama, Yoshihisa Kurachi

研究成果: Article査読

33 被引用数 (Scopus)

抄録

Stimulation-regulated fusion of vesicles to the plasma membrane is an essential step for hormone secretion but may also serve for the recruitment of functional proteins to the plasma membrane. While studying the distribution of G protein-gated K+ (K(G)) channels in the anterior pituitary lobe, we found K(G) channel subunits Kir3.1 and Kir3.4 localized on the membranes of intracellular dense core vesicles that contained thyrotropin. Stimulation of these thyrotroph cells with thyrotropin-releasing hormone provoked fusion of vesicles to the plasma membrane, increased expression of Kir3.1 and Kir3.4 subunits in the plasma membrane, and markedly enhanced K(G) currents stimulated by dopamine and somatostatin. These data indicate a novel mechanism for the rapid insertion of functional ion channels into the plasma membrane, which could form a new type of negative feedback control loop for hormone secretion in the endocrine system.

本文言語English
ページ(範囲)7969-7974
ページ数6
ジャーナルJournal of Biological Chemistry
274
12
DOI
出版ステータスPublished - 1999 3月 19
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 細胞生物学

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