Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody

Tetsuya Akaishi, Juichi Fujimori, Toshiyuki Takahashi, Tatsuro Misu, Yoshiki Takai, Shuhei Nishiyama, Kimihiko Kaneko, Ryo Ogawa, Michiaki Abe, Tadashi Ishii, Masashi Aoki, Kazuo Fujihara, Ichiro Nakashima

研究成果: Article査読

3 被引用数 (Scopus)

抄録

This study aimed to determine the seasonal impact on the clinical onset of inflammatory neurological diseases of the central nervous system by analyzing the onset month with information on clinical manifestations in Japanese patients. As a result, patients with anti-aquaporin-4 antibodies (AQP4-IgG)-positive neuromyelitis optica spectrum disorders (NMOSD) showed spring–summer predominance of the clinical onset. Conversely, patients with anti-myelin oligodendrocyte glycoprotein antibody (MOG-IgG)-associated disease showed autumn–winter predominance of the clinical onset. Both seasonal variations were irrespective of the clinical manifestation. Environmental factors with seasonal variation influence the development of neurological conditions related to AQP4-IgG and MOG-IgG.

本文言語English
論文番号577431
ジャーナルJournal of Neuroimmunology
349
DOI
出版ステータスPublished - 2020 12 15

ASJC Scopus subject areas

  • 免疫アレルギー学
  • 免疫学
  • 神経学
  • 臨床神経学

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