Scrapie-associated fibrils (SAF) purification method yields amyloid proteins from systemic and cerebral amyloidosis

Tetsuyuki Kitamoto, Kohtaro Hikita, Takatoshi Tashima, Jun Tateishi, Yuji Sato

研究成果: Article査読

5 被引用数 (Scopus)

抄録

We identified fibrils from non-transmissible systemic and cerebral amyloidosis using the purification method of scrapie-associated fibrils (SAF). The fibrils possessed the same nature of congophilia, filamentous structures and molecular weights as amyloid fibrils, and were resistant to Proteinase K digestion. This SAF method makes for a rapid extraction from amyloid-laden tissues. The method, therefore, may purify nontransmissible amyloids alone or together with SAF proteins.

本文言語English
ページ(範囲)459-465
ページ数7
ジャーナルBioscience Reports
6
5
DOI
出版ステータスPublished - 1986 5 1
外部発表はい

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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