Satratoxin H generates reactive oxygen species and lipid peroxides in PC12 cells

Punnee Nusuetrong, Thitima Pengsuparp, Duangdeun Meksuriyen, Masaaki Tanitsu, Haruhisa Kikuchi, Michinao Mizugaki, Ken Ichi Shimazu, Yoshiteru Oshima, Norimichi Nakahata, Makoto Yoshida

研究成果: Article査読

9 被引用数 (Scopus)

抄録

Satratoxin H, a mycotoxin, is thought to induce apoptosis of PC12 cells through the activation of p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) in a glutathione (GSH)-sensitive manner. The present study was undertaken to further elucidate the mechanism by which satratoxin H induces cell death in PC12 cells. Satratoxin H caused apoptosis of PC12 cells within 24-h, as determined by DNA fragmentation and flow cytometric analysis. Satratoxin H increased reactive oxygen species (ROS) production and lipid peroxidation, as determined by malondialdehyde formation. These effects were attenuated by incubation of cells with GSH, suggesting that satratoxin H-induced increase in apoptosis of serum-deprived PC12 cells may be partially mediated through the generation of ROS.

本文言語English
ページ(範囲)1115-1120
ページ数6
ジャーナルBiological and Pharmaceutical Bulletin
31
6
DOI
出版ステータスPublished - 2008 6 1

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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