Salivary levels of cortisol and chromogranin A in patients with dry mouth compared with age-matched controls

Chieko Shigeyama, Toshihiro Ansai, Shuji Awano, Inho Soh, Akihiro Yoshida, Tomoko Hamasaki, Yasuaki Kakinoki, Kazuhiro Tominaga, Tetsu Takahashi, Tadamichi Takehara

研究成果: Article査読

28 被引用数 (Scopus)

抄録

Objective: To evaluate the salivary levels of cortisol and chromogranin A (CgA) in patients with dry mouth (perceived xerostomia and hyposalivation) compared with age-matched controls. Study design: We studied 174 subjects, including those with dry mouth, classified into 2 subgroups based on perceived xerostomia and salivation, and those without (control subjects). The control subjects were patients at the same hospital and healthy volunteers. Cortisol and CgA levels in stimulated whole saliva were measured using ELISA kits. Results: All subjects with dry mouth had significantly higher cortisol and CgA levels than the control subjects. The statistical associations remained significant when they were divided into the 2 subgroups, although somewhat weaker associations were observed. The influences of xerogenic drugs were found to be minimal on salivary flow rate and levels of cortisol and CgA. Conclusions: We found significant associations between salivary cortisol and CgA levels and symptoms of oral dryness and reduced salivary flow.

本文言語English
ページ(範囲)833-839
ページ数7
ジャーナルOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
106
6
DOI
出版ステータスPublished - 2008 12月
外部発表はい

ASJC Scopus subject areas

  • 外科
  • 口腔外科
  • 耳鼻咽喉科学
  • 歯科学(全般)

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