Safety and efficacy of imidapril in the treatment of essential hypertension

Masashi Okamura, Susumu Ogawa, Sadayoshi Ito

研究成果: Review article査読

抄録

Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are one of the renin angio-tensin system (RAS) inhibitors widely used for the treatment of hypertension. Recently, Blood Pressure Lowering Treatment Trialists' Collaboration (BPLTTC) meta-analysis showed that ACEIs had the blood pressure independent beneficial effects on coronary heart events. In this review, we summarized our current knowledge about ACEIs especially imidapril and re-evaluated ACEIs among other RAS inhibitors (RASIs) because ACEIs have wide ranges of beneficial effects in addition to the ACE inhibition which other RASIs do not have such as the up-regulation of bradykinin level, substance P level, the inhibition of matrix metalloproteinase (MMP) activity and stabilization of coronary plaque.

本文言語English
ページ(範囲)477-486
ページ数10
ジャーナルClinical Medicine Insights: Therapeutics
3
DOI
出版ステータスPublished - 2011

ASJC Scopus subject areas

  • 薬理学
  • 薬科学

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