TY - JOUR
T1 - S100A10 upregulation associates with poor prognosis in lung squamous cell carcinoma
AU - Sato, Kimiaki
AU - Saiki, Yuriko
AU - Arai, Kazumori
AU - Ishizawa, Kota
AU - Fukushige, Shinichi
AU - Aoki, Kenko
AU - Abe, Jiro
AU - Takahashi, Satomi
AU - Sato, Ikuro
AU - Sakurada, Akira
AU - Okada, Yoshinori
AU - Horii, Akira
N1 - Funding Information:
We are grateful to Dr. Barbara Lee Smith Pierce (Adjunct Professor, University of Maryland University College) for her editorial work in the preparation of this manuscript, and to Dr. Satoshi Miyata for his statistical support. This work was supported in part by Grants-in-Aid for Scientific Research (JP26460468, JP15K100840, JP17K156610 and JP17K096410) from the Japan Society for the Promotion of Science.
Funding Information:
We are grateful to Dr. Barbara Lee Smith Pierce (Adjunct Professor, University of Maryland University College) for her editorial work in the preparation of this manuscript, and to Dr. Satoshi Miyata for his statistical support. This work was supported in part by Grants-in-Aid for Scientific Research ( JP26460468 , JP15K100840 , JP17K156610 and JP17K096410 ) from the Japan Society for the Promotion of Science .
Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2018/10/28
Y1 - 2018/10/28
N2 - S100A10 is one of the members of the S100 protein family and is a key plasminogen receptor. Its upregulation has been reported in many types of tumors. In lung cancer, an association between upregulation of S100A10 and poor prognoses has been reported only in adenocarcinoma. We pursued the possibility of significance in lung squamous cell carcinoma (SCC). We first examined S100A10 protein expression by immunohistochemistry in 120 primary resected lung SCCs; 33 (27.5%) tumors showed strong membranous-immunopositivity particularly at the invasive front, i.e., the cancer-cell surface in contact with the stroma. Expression levels were significantly associated with higher pathological TNM stage (P = 0.0119), tumor size (P = 0.0003), lymphatic invasion (P = 0.0005), lymph node metastasis (P = 0.0006), and poorer prognosis (P = 0.0064). Our present results suggest that high S100A10 expression of the lung SCC cells, particularly adjacent to stroma, plays an important role in tumor progression, probably caused by lymphatic invasion and nodal metastasis.
AB - S100A10 is one of the members of the S100 protein family and is a key plasminogen receptor. Its upregulation has been reported in many types of tumors. In lung cancer, an association between upregulation of S100A10 and poor prognoses has been reported only in adenocarcinoma. We pursued the possibility of significance in lung squamous cell carcinoma (SCC). We first examined S100A10 protein expression by immunohistochemistry in 120 primary resected lung SCCs; 33 (27.5%) tumors showed strong membranous-immunopositivity particularly at the invasive front, i.e., the cancer-cell surface in contact with the stroma. Expression levels were significantly associated with higher pathological TNM stage (P = 0.0119), tumor size (P = 0.0003), lymphatic invasion (P = 0.0005), lymph node metastasis (P = 0.0006), and poorer prognosis (P = 0.0064). Our present results suggest that high S100A10 expression of the lung SCC cells, particularly adjacent to stroma, plays an important role in tumor progression, probably caused by lymphatic invasion and nodal metastasis.
KW - Invasion
KW - Lung squamous cell carcinoma
KW - Metastasis
KW - Prognosis
KW - S100A10
UR - http://www.scopus.com/inward/record.url?scp=85053883916&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85053883916&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2018.09.118
DO - 10.1016/j.bbrc.2018.09.118
M3 - Article
C2 - 30268496
AN - SCOPUS:85053883916
SN - 0006-291X
VL - 505
SP - 466
EP - 470
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -
