Roles of the primary cilium component polaris in synchondrosis development

T. Ochiai, M. Nagayama, T. Nakamura, T. Morrison, D. Pilchak, N. Kondo, H. Hasegawa, B. Song, R. Serra, M. Pacifici, E. Koyama

研究成果: Article

12 引用 (Scopus)


Primary cilia regulate several developmental processes and mediate hedgehog signaling. To study their roles in cranial base development, we created conditional mouse mutants deficient in Polaris, a critical primary cilium component, in cartilage. Mutant post-natal cranial bases were deformed, and their synchondrosis growth plates were disorganized. Expression of Indian hedgehog, Patched-1, collagen X, and MMP-13 was reduced and accompanied by decreases in endochondral bone. Interestingly, there was excessive intramem- branous ossification along the perichondrium, accompanied by excessive Patched-1 expression, suggesting that Ihh distribution was wider and responsible for such excessive response. Indeed, expression of heparan sulfate proteoglycans (HS-PGs), normally involved in restricting hedgehog distribution, was barely detectable in mutant synchondroses. Analyses of the data provides further evidence for the essential roles of primary cilia and hedgehog signaling in cranial base development and chondrocyte maturation, and point to a close interdependence between cilia and HS-PGs to delimit targets of hedgehog action in synchondroses.

ジャーナルJournal of dental research
出版物ステータスPublished - 2009 6 1

ASJC Scopus subject areas

  • Dentistry(all)

フィンガープリント Roles of the primary cilium component polaris in synchondrosis development' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Ochiai, T., Nagayama, M., Nakamura, T., Morrison, T., Pilchak, D., Kondo, N., Hasegawa, H., Song, B., Serra, R., Pacifici, M., & Koyama, E. (2009). Roles of the primary cilium component polaris in synchondrosis development. Journal of dental research, 88(6), 545-550.