Roles of MAPKKK ASK1 in stress-induced cell death

Kohsuke Takdea, Atsushi Matsuzawa, Hideki Nishitoh, Hidenori Ichijo

研究成果: Review article査読

184 被引用数 (Scopus)

抄録

Apoptosis signal-regulating kinase 1 (ASK1) is a ubiquitously expressed mitogen-activated protein (MAP) kinase kinase kinase that activates the c-Jun N-terminal kinase (JNK) and p38 MAP kinase signaling cascades. Recent findings from analyses of ASK1-deficient mice have revealed that ASK1 is required for apoptosis induced by oxidative stress, TNF and endoplasmic reticulum (ER) stress. In addition, several lines of evidence have suggested that ASK1 has diverse functions in the decision of cell fate beyond its pro-apoptotic activity. Thus, ASK1 appears to be a pivotal component not only in stress-induced cell death but also in a broad range of biological activities in order for cells to adapt to or oppose various stresses.

本文言語English
ページ(範囲)23-29
ページ数7
ジャーナルCell structure and function
28
1
DOI
出版ステータスPublished - 2003 2

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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