Role of the ubiquitin-proteasome system in methylmercury toxicity in Saccharomyces cerevisiae

Gi Wook Hwang

研究成果: Review article査読

6 被引用数 (Scopus)


Methylmercury (MeHg) is an important environmental pollutant that causes severe disorders of the central nervous system, but the mechanism underlying its toxicity and the corresponding biological defense mechanisms remain largely unknown. Saccharomyces cerevisiae (S. cererisiae) yeast cells were used to elucidate the defense mechanisms against MeHg toxicity and to search for novel genes involved in MeHg resistance. S. cerevisiae is a eukaryotic organism that possesses many gene products that are functionally similar to those of mammals such as humans. We have previously reported that Cdc34 and Rad23 confer MeHg resistance to yeast cells. Interestingly, the both proteins are related to ubiquitin-proteasome system (UP system) that is involved in the intracellular degradation of proteins. In our detailed experiments, we found that the UP system might play an important role in lending protection against MeHg toxicity. This review summarizes the results of our studies on the role of the UP system as a defense mechanism against MeHg toxicity in yeast cells.

ジャーナルJournal of Health Science
出版ステータスPublished - 2011 4月

ASJC Scopus subject areas

  • 毒物学
  • 健康、毒物学および変異誘発


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