Role of prolyl isomerase Pin1 in pathogenesis of diseases and remedy for the diseases from natural products

Katsuhiko Takahashi, Taiki Shimizu, Keita Kosaka, Masafumi Hidaka, Chiyoko Uchida, Takafumi Uchida

研究成果: Article査読

8 被引用数 (Scopus)

抄録

The peptidyl prolyl cis/trans isomerase Pin1, the human ortholog of yeast Ess1 specifically isomerizes peptide bindings of pSer/pThr-Pro residues in various proteins, and regulates the expression levels and functions of phosphorylated proteins. Activation of Pin1 is associated with pathology of a variety of diseases, such as cancer, Alzheimer’s disease, infectious diseases and so on. Therefore, regulatory compounds for Pin1 can be applied as a clinical medicine against these diseases. Many chemists have exerted themselves to synthesize the inhibitors based on the 3D structure of Pin1. We have screened for the inhibitors against Pin1 from the natural products including the functional foods. Here we review the Pin1-associated pathology and the known inhibitors identified from natural products. And we introduce the screening methods targeting Pin1 activity.

本文言語English
ページ(範囲)973-981
ページ数9
ジャーナルCurrent Drug Targets
15
10
出版ステータスPublished - 2014 1 1

ASJC Scopus subject areas

  • 分子医療
  • 薬理学
  • 創薬
  • 臨床生化学

フィンガープリント

「Role of prolyl isomerase Pin1 in pathogenesis of diseases and remedy for the diseases from natural products」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル