Role of osteoclast in preferential alignment of biological apatite (BAp) in long bones

Jee Wook Lee, Takayoshi Nakano, Satoru Toyosawa, Naokuni Ijuhin, Yasuhiko Tabata, Masaya Yamamoto, Yukichi Umakoshi

研究成果: Conference contribution

13 被引用数 (Scopus)

抄録

Absorption and formation of hard tissues are repeated in vivo by the activity of osteoclast and osteoblast, respectively. The preferential alignment of BAp or collagen fibril is thought to be closely related to the activity of the bone cells. In this study, changes in bone mineral density (BMD) and preferential alignment of biological apatite (BAp) were examined focusing on the role of osteoblast using the model of osteopetrotic (op/op) mice in which osteoblast activity was normal but the expression of osteoclast was reduced. Osteopetrotic (op/op) mice and their normal littermates aged 5, 12 and 24 weeks were analyzed. The BMD and BAp texture of femoral diaphysis were measured using peripheral quantitative computed tomography (pQCT) and a microbeam X-ray diffractometer system with a 50 μmφ diameter beam spot respectively. The decrease in osteoclast expression induced both the reduction of the skeletal system and calcification of the medullary cavity, which are typical features of osteopetrosis. As a result, the shape, BMD and preferential BAp alignment of the femur in the op/op mice were remarkably different from those in the control group. At the center of the femoral diaphysis, BMD in the cortical area showed no significant difference between the two groups, but preferential alignment of the BAp c-axis in the op/op mice group had a lower value than that in the control group. This suggests that the decrease in the number of osteoclasts suppresses normal remodeling, resulting in a decrease in bone quality, especially the preferential alignment of the BAp c-axis.

本文言語English
ホスト出版物のタイトルAdvanced Structural and Functional Materials Design - Proceedings of the International Symposium on Advanced Structural and Functional Materials Design, 2004
出版社Trans Tech Publications Ltd
ページ265-268
ページ数4
ISBN(印刷版)0878499962, 9780878499960
DOI
出版ステータスPublished - 2006
外部発表はい
イベントInternational Symposium on Advanced Structural and Functional Materials Design, 2004 - Osaka, Japan
継続期間: 2004 11 102004 11 12

出版物シリーズ

名前Materials Science Forum
512
ISSN(印刷版)0255-5476
ISSN(電子版)1662-9752

Other

OtherInternational Symposium on Advanced Structural and Functional Materials Design, 2004
国/地域Japan
CityOsaka
Period04/11/1004/11/12

ASJC Scopus subject areas

  • 材料科学(全般)
  • 凝縮系物理学
  • 材料力学
  • 機械工学

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