Role of natural killer cells in intraocular melanoma metastasis

T. Yokoyama, O. Yoshie, H. Aso, T. Ebina, N. Ishida, K. Mizuno

研究成果: Article査読

5 被引用数 (Scopus)

抄録

The authors studied the role of natural killer (NK) cells in spontaneous metastasis of murine intraocular melanoma by transplanting murine B16 melanoma cells into the anterior chamber of the eye in syngeneic C57BL/6 mice and determining the number of metastatic lung tumor colonies after 40 days. Depletion of NK activity by anti-asialo GM1 serum dramatically enhanced metastasis and augmentation of NK activity by interferon inhibited it. The strong correlation between host NK activity and intraocular melanoma metastasis indicated that NK cells have an important role in spontaneous metastasis of intraocular melanoma.

本文言語English
ページ(範囲)516-518
ページ数3
ジャーナルInvestigative Ophthalmology and Visual Science
27
4
出版ステータスPublished - 1986

ASJC Scopus subject areas

  • 眼科学
  • 感覚系
  • 細胞および分子神経科学

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